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Re: reboxetine combo

Posted by Scott L. Schofield on December 30, 1999, at 7:59:23

In reply to reboxetine combo, posted by drs on December 18, 1999, at 15:12:24

> Hi,
> I've been on Reboxetine at 8mg/day for 12 days now. I'm feeling no improvement and actually have been feeling much worse since I started taking it. The side effects haven't been very bothersome, but my mind is totally numb and I feel like a complete zombie. I know it's too early to quit but things are so shitty that I'm really tempted to drop it. Has anyone experienced anything similar?
> Also, does anyone know anything about combining reboxetine with adrafinil?

This sounds very similar to the way I have felt early on during trials of imipramine and desipramine, both of which are rather potent reuptake inhibitors of norepinephrine. Reboxetine is also a potent and selective NE reuptake inhibitor. It may be that the zombie-effect is a shared side-effect among these noradrenergic drugs. Anyway, I experienced this side-effect for a week or more, and then it disappeared.

Of course, the side-effect that you are experiencing may not relate at all to my experiences with the tricyclics. Because there is a chance that it may abate over time, I would suggest hanging in there a little longer with it.

- Scott




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