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Re: Nardil and MAOI dosages

Posted by Elizabeth on December 10, 1999, at 1:27:01

In reply to Nardil and MAOI dosages, posted by Mark on December 9, 1999, at 17:54:58

> Can Nardil, or any other MAOI, be taken all at once (entire daily dosage at once). Why is it necessary to split up the dose? Do MAOIs have short half-lives like the benzos, or is it due to blood pressure reasons?

The irreversible MAOIs have really short elimination half-lives, but that's not the reason (the half-life of an irreversible MAOI won't affect the % MAO inhibition). Splitting the dose may minimize side effects by spreading them out.

Many doctors will recommend you try to take it all in the morning or early afternoon to avoid insomnia, but my experience has been that it doesn't make a difference what time of day you take them (with the exception of Parnate, which is kind of stimulating) - the insomnia happens regardless!




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