Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Nardil and GABA

Posted by JohnB on December 8, 1999, at 21:01:58

In reply to Nardil and GABA, posted by Elizabeth on December 8, 1999, at 19:19:28

Hi, Elizabeth. I've copied and pasted an article, below, regarding Phenelzine's GABA elevating effects. There are, of course, many additional articles on MedLine, available through a no-cost PubMed search. My take on this article is that PLZ exerts its GABA elevating effects through inhibition of the anabolic enzyme glutamic acid decarboxylase (GAD) and, to a greater extent, the catabolic enzyme GABA transaminase (GABA-T)." Unfortunately, I wasn't able to find anything regarding the GABA elevating properties of Marplan, except an article suggesting complete GABA receptor blockage when Marplan is used in conjunction with Clozapine (an anti-psychotic.)



Chronic administration of the antidepressant phenelzine and its N-acetyl analogue: effects on GABAergic function.

McKenna KF, McManus DJ, Baker GB, Coutts RT
Department of Psychiatry, University of Alberta, Edmonton, Canada.

The MAO inhibitor phenelzine (2-phenylethylhydrazine; PLZ) is used widely in psychiatry for the treatment of depression and panic disorder. Its N-acetyl metabolite, N2-acetylphenelzine (N2AcPLZ) is a reasonably potent nonselective inhibitor of monoamine oxidase (MAO) that causes elevation in brain levels of the biogenic amines. In the studies reported here, PLZ (0.05 mmol/kg/day), N2AcPLZ (0.10 mmol/kg/day) or vehicle were administered to male rats for 28 days s.c. with Alzet minipumps, and their effects on GABAergic function were examined. Whole brain concentrations of gamma-aminobutyric acid (GABA) were significantly elevated in the PLZ but not in the N2AcPLZ-treated group. PLZ was found to inhibit the anabolic enzyme glutamic acid decarboxylase (GAD) and, to a greater extent, the catabolic enzyme GABA transaminase (GABA-T). The results of these investigations suggest that the free hydrazine moiety in PLZ is crucial to producing the elevated levels of GABA, probably through inhibition of GABA-T. Despite the considerable increase in whole brain GABA levels in the PLZ-treated rats, there were no significant differences in GABAA or benzodiazepine receptor binding parameters (KD or Bmax) between the groups as measured using 3H-muscimol and 3H-flunitrazepam in radioligand binding assays.

PMID: 7931216, UI: 95016587




Post a new follow-up

Your message only Include above post

Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:JohnB thread:16450