Posted by Elizabeth on December 8, 1999, at 19:19:28
Hey everybody.
Nardil, or one of its metabolites rather, is known to increase brain GABA concentrations by inhibiting GABA transaminase. This is believed to be related to its hydrazine structure, but I can't find any information on whether Marplan (also a hydrazine derivative) does this as well. I'm wondering if anybody knows the exact mechanism. For some reason I'm thinking it has to do with pyridoxal phosphate (i.e., vitamin B6) depletion (like, the metabolite forms a complex with p5p that inhibits GABA-T) but I have no idea where I might have read that (can't find anything about it anywhere). Anybody know more?
poster:Elizabeth
thread:16450
URL: http://www.dr-bob.org/babble/19991123/msgs/16450.html