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Re: joining research studies, any opinions?

Posted by Adam on December 7, 1999, at 9:39:13

In reply to Re: joining research studies, any opinions?, posted by Noa on December 7, 1999, at 2:55:27

If I understand correctly, transdermal delivery of selegiline has the
following advantages over oral delivery:

-More even dosing (mostly relevant to side-effects of metabolites).

-Preferential pharmacokinetics: First-pass metabolism is avoided (there
is very little metabolism of selegiline in the skin compared to the gut)
and so the effective dose of the parent compound is increased. Hence,
you get more l-selegiline/mg (and less overall metabolite production;
since two of the metabolites of selegiline are amphetamines, this is
probably a Good Thing (TM))

-No dietary restrictions: Somehow monoamine oxidase in the intestinal
lining is not sufficiently inhibited to prevent the breakdown of
tyramine when selegiline is delivered transdermally. I have a feeling
the lining of blood vessels in the intestinal wall allows selegiline to
pass in only one direction, outside to inside. I've eaten and drunk
copious amounts of forbidden foods, and have had absolutely no
problems related to b.p.

The only disadvantage I can think of is I have to stick this little
thing to myself every day. I prefer swallowing a pill, but it really
isn't a big deal.

> Is the advantage of a patch delivery system a more constant, consistant flow of med into one's system? Is ther a future for patches in other psychmeds?




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