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Re: You never know-Nardil vs. Parnate

Posted by Elizabeth on December 6, 1999, at 20:14:56

In reply to Re: You never know-Nardil vs. Parnate, posted by Adam on December 6, 1999, at 12:11:30

>...Anyway, I thought it might be connected to b.p. somehow, since orthostasis gave some relief.

Huh - did you try taking your BP?

> I went to see my doctor, got checked out by Dr. Bodkin instead, and had a little discussion
> about spontaneous hypertension (the weirdness went away on its own-maybe just a bug). He said
> spont. hyp. was almost exclusively a "Parnate effect", and was related to the stimulant
> properties of tranylcypromine metabolites. Essentially the drug can have adverse interactions
> with itself.

Yup, that's what he told me too.

> He also said that they've "thrown everything but the kitchen sink" at selegiline
> to try to get the same thing to occur, and the conclusion was that spont. hyp. "simply does
> not happen" with that drug.

...which is terribly interesting given selegiline's pharmacokinetic profile (I tested positive for amphetamines at one point when I was on it). I wonder about the d and l forms too; may look that up later on....

> So I guess I'm wondering,
> could selegiline metabolites somehow inhibit NE release (which is why you never see spont. hyp.
> in people taking it), and could it even be an antidote to spont. hyp.? Could a low dose of
> selegiline be combined with Parnate to prevent this from occuring?

Oh god. Don't go least not in humans!

> I know, ridiculous idea, probably, but something I figured I'd ask.

Kids, don't try this at home! :)




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