Psycho-Babble Medication | about biological treatments | Framed
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Re: To: Scott Marplan titration, clonidine, orgasm

Posted by Scott L. Schofield on November 27, 1999, at 17:43:49

In reply to To: Scott Marplan titration, clonidine, orgasm, posted by George M on November 22, 1999, at 22:32:06

> Are you using it for social phobia? Does it also work for you? I've heard clonidine and marplan are very effective at blocking gaba receptors. Might be a better combination than pindolol and marplan.
> Lastly, have you found any effective treatment for anorgasmia?

First things first. You couldn't possibly be asking any more wrong a person regarding anorgasmia with MAO-inhibitors. I committed the cardinal sin of applying my own experiences to everyone else. I was politely reprimanded for doing so. Anyway, when I saw some people posting their experiences with anorgasmia as an MAOI side-effect, I posted a question to get an idea as to how pervasive a problem it is. It really wasn't meant to be any kind of 'study', but I was truly taken back at how many people replied that they had some big-time trouble reaching orgasm.

Follow the thread starting from:
My newly prescribed "social phobia" meds - fyi

I think you'll find some good answers to your questions there.
(Feel free to disregard my "make-ass" comments and subsequent replies).

I've been on Marplan for a little over two weeks at a dosage of 30mg per day. Nothing yet. I haven't noticed any substantial side-effects either. Some people here have posted that they were taking 50 to 80 mg/day, so there is still room for hope.

I suffer from chronic bipolar depression that's pretty heavy-duty. Nardil and Parnate were only partially effective, even when combined with a tricyclic, amphetamine, and thyroid at the same time. Social-phobia was a real big part of things early on. I don't know - maybe I no longer have enough energy to be phobic about anything. After a little mental rearranging, I seem to be left with something less than phobia but bigger than a bread-box. The French have called this sort of thing "l'inhibition". I certainly do feel inhibited around others.

I'm keeping pindolol on my short-list of things to add to an MAOI.
A combination of buspirone and pindolol seems interesting also. As far as clonidine having GABAergic effects, you've got me curious, so I think I'll look into that.

I'll post every now and again to let you know how I'm doing.


- Scott




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