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Re: Lofepramine and tricyclics

Posted by George O. on April 16, 1999, at 17:20:13

In reply to Re: Lofepramine and tricyclics, posted by saintjames on April 16, 1999, at 0:13:56

> i've looked it up on the web and there is very little information about
> > this drug and what little there is seems to say that
> > lofepramine and tricyclics in general are 'dirty' drugs
> > and not terribly reccommended. does anyone have anything good
> > to say at all about tricyclics?
> James here....
> TCA's are still the gold standard that all AD's are measured against (~70% of depressives will improve on TCA's) "Dirty" means that TCA's effect many systems and not just mood neurochems. The newer AD's tend to be specific or selective in their action so they (hopefully) have fewer side effects. But as mood is a multi faceted animal that we are just understanding often "dirty" meds
> work better in some cases...hince poly drug thearpy for resistant depression.
> Can't comment on lofepramine

The only long term success (2yrs or more) I've ever had has been with tricyclics, ssr's sedate me heavily, other new stuff doesn't work. The number one advantage of newer ad'd is that they are not so lethal in cases of overdose. I did a lot of reading on lofepramine, what I can quickly recall is that it is derived from imiprimine (similar to desiprimine, in fact a small portion of lofepramine is converted to desiprimine within the body). Lofepramine is easier on the heart and liver
, it's also not usually sedating. I haven't found it to be very effective, but then again I had already taken desiprimine for years and become resistant to it, the two drugs are awfully closely related. George




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