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Re: Lofepramine and tricyclics

Posted by saintjames on April 16, 1999, at 0:13:56

In reply to Lofepramine and tricyclics, posted by Andie on April 13, 1999, at 11:07:08

i've looked it up on the web and there is very little information about
> this drug and what little there is seems to say that
> lofepramine and tricyclics in general are 'dirty' drugs
> and not terribly reccommended. does anyone have anything good
> to say at all about tricyclics?

James here....

TCA's are still the gold standard that all AD's are measured against (~70% of depressives will improve on TCA's) "Dirty" means that TCA's effect many systems and not just mood neurochems. The newer AD's tend to be specific or selective in their action so they (hopefully) have fewer side effects. But as mood is a multi faceted animal that we are just understanding often "dirty" meds
work better in some cases...hince poly drug thearpy for resistant depression.

Can't comment on lofepramine





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