Psycho-Babble Medication | about biological treatments | Framed
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Re: OK to Take Entire BuSpar Dose at Bedtime?

Posted by JohnL on November 20, 1999, at 4:43:12

In reply to OK to Take Entire BuSpar Dose at Bedtime?, posted by David Mirtzer on November 19, 1999, at 13:57:54

I dunno David. That's a good question. Buspar's half life is fairly short, just a few hours. But other short half life meds, like Serzone, seem to work just as well taken once nightly instead of bid or tid. According to anecdotal and clinical evidence anyway. Buspar's metabolite has considerable pharmacological action in the body and may contribute to its efficacy. I don't know if anyone knows for sure how its metabolite contributes to the overall picture. But Buspar's metabolite is actually stronger than the parent compound, has a different action, and a much longer half life. So maybe once-nightly dosing stands a chance of working.

I think you know though that the only real way to answer your question is to try it and see. Even if it had worked with someone else, there would be no way to predict it would work with you too. Right? Just gotta try it and see. If someone was at a higher dose, say maybe 60mg or 90mg, they would be taking your dose all at once two or three times a day. So it should be a safe experiment to try. I would think those fatique side effects would have diminished after 6 weeks. But they haven't, huh? If the side effects are still with you in another 2 to 4 weeks, then I think it would be a safe assumption that they aren't going to go away. Hmmm, I dunno know. That's a tough one too. You ask some tough questions! :)




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