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Re: Atypical side effects. Back to Prozac.

Posted by JohnL on November 20, 1999, at 4:09:21

In reply to Atypical side effects. Back to Prozac., posted by JohnL on November 14, 1999, at 4:02:32

> I recently switched to Moclobemide from Prozac. Prozac worked OK, but no effect on my anhedonia. I had an atypical side effect with it...greatly increased sexual function in all areas (desire, libido, erection). The best sex of my life. On Prozac? Go figure. Moclobemide is touted as having no sexual side effects. One doc has had 100% success in switching patients with SSRI sexual dysfunction to Moclobemide. But I've found Moclobemide has totally and completely wiped out any sexual interest. It's gone and I can tell it's not going to come back. And the anorgasmia is so severe that a sexual encounter ends as unfinished business. Not to mention an unmaintainable erection. My sexual responses to both Prozac or Moclobemide are exactly the opposite of the norm.
> I'm going back to Prozac! The awesome sexual relationship with my wife is just too much to miss out on. We both miss it already. I'll have to find another way to tweek the Prozac to deal with the anhedonia. Perhaps back to Naltrexone except at a higher dose (up to 100mg?). Perhaps adding a TCA on the side. Wellbutrin or Lithium (if I can accept the tinnitus). Or maybe something I haven't tried like a dopamine agonist of some kind.
> We all talk about how we respond so differently to various drugs. We all know how true that is. But still I am just so amazed and counfounded at the atypical side effects I have experienced from Moclobemide and Prozac. Anyway, we live and learn, right?

After a week off Moclobemide and back on Prozac, the vital parts seem to be coming back to life. (whew!) My wife said , "Welcome back"! I was starting to panic that maybe I screwed things up badly and would never regain my baseline on Prozac again. Amazing. It still confounds me how our individual side effects/responses to different meds can vary so mysteriously.

Now what to do about the stubborn anhedonia is the focus. I still have plenty of leftover meds in my sock-drawer pharmacy, and I think upping the Prozac dose and adding a TCA is what my pdoc will like the best. He still wants me to give Naltrexone more of a chance too, up to 100mg rather than the 25mg I tried previously. Whatever I do, I gotta be careful not to screw up the mix and lose any ground like I did on Moclobemide. At least if I'm going to continue being only a partial responder, a good sex life is highly appreciated! :)




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