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Re: Buspar - "partial" agonist?

Posted by Rick on November 18, 1999, at 1:17:12

In reply to Buspar - "partial" agonist?, posted by Scott L. Schofield on November 17, 1999, at 11:42:07

The following site addresses your questions and related issues. This is a page from the middle of the presentation, but the bullet point at the end is particularly pertinent (...and surprising: it suggests that a Buspar/pindolol combination has a potent and rapid-onset antidepressant effect).


> I often see buspirone (Buspar) described as being a "partial" agonist at 5-HT1a receptor sites.
> 1. What does "partial" mean?
> (pre-synaptic vs post-synaptic?)
> 2. As an agonist, wouldn't it work against the antagonist activity of pindolol?
> Thanks.
> Scott




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