Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

T4 for treatment resistant depression

Posted by andrewb on November 16, 1999, at 15:37:09

The thyroid hormone T4 may be effective in treating treatment resistant depression according to the abstract of the study quoted below. For lots more info. on strategies for dealing with treatment resistant depression see Ivan Goldberg’s ‘Depression Central’ website at
Source Biol Psychiatry 1999 Jan 15;45(2):229-33
Title Treatment of refractory chronic depression and dysthymia with high-dose
Author Rudas S, Schmitz M, Pichler P, Baumgartner A
Address Community Mental Health Service of Vienna, Austria.

BACKGROUND: An 8-week open trial was conducted to investigate whether patients
with treatment-resistant, chronic depression and/or dysthymia could profit from
high-dose thyroxine (T4) augmentation. METHODS: Nine patients whose current
depressive episode had lasted for a mean of 15.5 +/- 8.6 months (range: 2-30
months) received T4 in addition to their current medication. RESULTS: Two
patients dropped out of the study owing to side effects. The remaining 7
patients received a final mean dose of T4 of 235 +/- 58 micrograms/day (range:
150-300 micrograms/day). Their scores on the Hamilton Depression Rating Scale
had fallen from a mean of 21.1 +/- 4.1 before inclusion in the study to a mean
of 8.0 +/- 2.8 at the end of the 8th week. Five patients were full responders,
1 a partial responder, and 1 a nonresponder. CONCLUSIONS: Augmentation with
high-dose T4 proved to have an antidepressant effect in more than 50% of the
previously treatment-resistant patients with chronic depression and/or




Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:andrewb thread:15315