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Re: Out-of-sorts w/Prozac/Adderall/Elavil(TCA)

Posted by JohnL on November 8, 1999, at 14:44:58

In reply to Out-of-sorts w/Prozac/Adderall/Elavil(TCA), posted by dove on November 8, 1999, at 12:27:53

Hi Dove. There are enzymes that break down the drugs we take. Prozac strongly inhibits a particular enzyme that breaks down other drugs. It varies from person to person, but Prozac has the potential of drastically increasing the amounts of other drugs in the blood by interfering with their breakdown. This may apply to the Adderall, but it definitely applies to the Amitriptyline. When you introduced Prozac into your system, you basically increased the doses of the other meds anywhere from 2 to 11 times all at once. That's why you're feeling so out of sorts.

The combination of meds you are taking looks OK to me. Nothing weird here. But one must be aware that Prozac will increase the blood levels of other drugs, exactly as if you had increased the doses of them all. Personally I would bring the Prozac way back down to perhaps 5mg or 10mg a day (empty in water or juice to custom dose), or cut the doses of the others in half. TCAs are deadly in overdose, and the Prozac raises the TCA levels when combined. That's why the pharmacist was worried about killing yourself. To be safe, and comfortable with side effects, it sounds to me like the dose of the Prozac be reduced, or the others, or even everything. Get used to a certain level before tweeking higher. The doses you are currently taking are normal, but it's better I think to adjust to side effects at a lower level before moving up. 20mg Prozac, in addition to the other stuff, in just one week, would be pretty hefty to a lot of us.




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