Posted by Rick on November 7, 1999, at 21:13:22
In reply to Re: Any SSRI/other? good as Nardil for Social Phobia?, posted by JOHNB on November 6, 1999, at 13:56:44
JohnB, be v-e-r-y careful if you try idea #4 with Nardil+Selegiline. It turns out the warnings about mixing MAOI's can be true! While I was still on Nardil for Social Phobia, my pdoc added a small dose (5 mg) of Selegiline.
Not only did this NOT help sexual function return, but I also found that about a half hour after taking the two meds together, my blood pressure would rise to DANGEROUSLY high levels (e.g. I'd jump from 110/75 to 200/110). I was totally asymptomatic (perhaps because I've had high BP in the past), but for others this kind of jump could result in a hypertensive crisis with serious consequences. The BP would go back down to normal levels within another 30-60 mins., but this is NOT something to fool around with!!! I was stupid to keep taking the combo, even for just a week.
After this we dumped the Nardil completely and went a little higher on the Selegiline. Eventually, we moved (thank God) to Klonopin.
BTW, for Social Phobia NO MED has EVER shown as great an effect vs. placebo (double-blind, controlled, large sample) as Klonopin did in Dr. Davidson's landmark 12/93 study at Duke. The results were 78% significant improvement for Klonopin (clonazepam) vs. 20% for placebo. The Medline (Pub Med) abstract is at the url below. I urge you to order the complete article.
Regardless, BE WARY OF A NARDIL+SELEGILINE COMBO!!!!
Rick
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8120156&form=6&db=m&Dopt=b
> THANKS, CRAIG. I'LL BE SEEING MY PSYCHDOC IN ABOUT A WEEK TO DISCUSS A CHANGE IN MEDS. HE'S A GOOD PSYCHOPHARMACOLOGIST, AND IS WILLING TO GIVE MOST THINGS A TRY, INCLUDING BUPROPION + MAOI'S, EVEN THOUGH THIS IS CONTRAINDICATED IN THE CONSERVATIVE DRUG HANDOUT LITERATURE. THE 4 ALTERNATIVES:
> (1) HIGH DOSE BUSPAR (60MG/DAY). PUB MED ARTICLE. (2) HIGH DOSE NEURONTIN (3600 MG/DAY). FOUND A PUBMED ARTICLE BY PARKE-DAVIS SUGGESTING THIS HIGH DOSE WAS EFFECTIVE FOR SP.
> (3) ZOLOFT OR SERZONE IN COMBINATION WITH BUSPAR (40MG/DAY). AGAIN, RAN ACROSS PUBMED CONTROLLED STUDY IN WHICH BUSPAR ENHANCES THE ANTI-PHOBIC EFFECT OF SSRI'S AND OTHER AD'S
> (4) NARDIL, PLUS SOMETHING TO COUNTERACT ITS EFFECT UPON APETITE AND SEXUAL DYSFUNCTION - MAYBE DOPAMINE AGONISTS, SUCH AS BUPROPION OR SELEGILINE.
>
> WILL POST BACK ABOUT WHAT I TRY AND IT'S EFFECT.
>
> THANKS, CRAIG. JOHNB :)
poster:Rick
thread:14476
URL: http://www.dr-bob.org/babble/19991028/msgs/14777.html