Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: MAOI's

Posted by Elizabeth on November 3, 1999, at 12:47:12

In reply to Re: MAOI's, posted by JohnL on November 3, 1999, at 3:17:29

> Hi James. You probably already know this, but Selegiline at 15mg or less (+ -) is void of the cheeze reaction. The reversible MAOI is Moclobemide. There is another similar one too. The name escapes me. Both are in other countries. Not USA. Moclobemide seems to be the most popular reversible MAOI. No cheeze reaction.

Two others that are available in some places (though less widely) are toloxatone and brofaromine. What I have heard about moclobemide mostly suggests that it's very hit-or-miss and that it just doesn't work as well as the irreversible, nonselective MAOIs, in general. This is why I haven't bothered trying it (too much hassle for something that might not even be worth it).

Reversibility just means that the MAO can be "recaptured" -- it's not effectively destroyed by moclobemide. When a molecule of phenelzine, say, hits MAO, they interact in such a way as to turn the MAO into something completely different that will no longer function as an enzyme.

> Moclobemide primary inhibits MAOs of serotonin and NE, with about 30% inhibition of dopamine MAO.

The more common names for these two are MAO-A and MAO-B. Tyramine is an MAO-B substrate; because moclobemide only has a modest affinity for MAO-B, it's easily displaced by tyramine.

> Don't know if it's available in Mexico.

It might be, under the brand name Aurorix.




Post a new follow-up

Your message only Include above post

Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:Elizabeth thread:14470