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Re: ? for Saint J: dexe vs Adderall

Posted by saint james on October 21, 1999, at 2:10:14

In reply to ? for Saint J: dexe vs Adderall, posted by dove on October 18, 1999, at 10:24:33

> S.J. wrote:
> I also question the use of L-amphetamine, as it has negative side effects. Another "least patentable difference" ?

James here...

Adderal was on the market as Orbitol till the 70's, was pulled because of abuse. Was re-introduced as Adderal as of late.

Adderal is a 50/50 mix of D and L amphetamine.
D and L refer to isomers, isomers mean a chemical with the same # of atoms, but in a different arrangement. D is "left handed" arrangement, L is the right. Biology mostly runs on D isomers, the universe is rather left handed, though there are exceptions, like the aminos. Look on the net about isomers, you really need graphics to understand this ! Many times the L is not active in humans, or is not useful, or has negative side effects.

Dex is all d-amphetamine, proven to be active in humans. L-amphetamine has some action, but tends to have more negative effects. Reported are: makes you more shakey, dysphoria, sweaty, ect.
The D vers is more smooth feeling.

"Least patentable difference" is the least chemical difference you can change a compound from the patent to get another patent. In this case it is the addition of L-amphetamine, and a few other things.





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