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Re: reply to andrewb & Buprenorphine 4 depression

Posted by Adam on October 20, 1999, at 17:56:13

In reply to Re: reply to andrewb & Buprenorphine 4 depression , posted by Diane on October 20, 1999, at 16:34:49

If my memory serves me, that abstract was written by Dr. JA Bodkin. I might see him in a week, or at least
someone who works with him. I suppose I could ask a couple questions, if you had any Dianne. They're pretty
nice there, and the doc I'm working with, if he isn't pressed for time, actually likes talking psychoparm
with me, so perhaps I could gather info.

> > You have an interesting story! Buprenorphine has been used to treat depression and is legally available without prescription from overseas.
> > >
> YOU wounldn't happen to have a particular vendor in mind would you?
> I'd be VERY interested in that. Do you think
> I was under the impression it was controlled same as Methadone.
> but then I never even thought of overseas with regard to Buprenorphine. DAH!
> Thanks I'm excited now.
> Here's a what I believe they call an abstract. I found it here at:
> " Opiates were used to treat major depression until the mid-1950s. The advent of opioids with
> mixed agonist-antagonist or partial agonist activity, with reduced dependence and abuse
> liabilities, has made possible the reevaluation of opioids for this indication. This is of potential
> importance for the population of depressed patients who are unresponsive to or intolerant of
> conventional antidepressant agents. Ten subjects with treatment-refractory, unipolar,
> nonpsychotic, major depression were treated with the opioid partial agonist buprenorphine in an
> open-label study. Three subjects were unable to tolerate more than two doses because of side
> effects including malaise, nausea, and dysphoria. The remaining seven completed 4 to 6 weeks of
> treatment and as a group showed clinically striking improvement in both subjective and objective
> measures of depression. Much of this improvement was observed by the end of 1 week of
> treatment and persisted throughout the trial. Four subjects achieved complete remission of
> symptoms by the end of the trial (Hamilton Rating Scale for Depression scores moderately improved, and one deteriorated. These findings suggest a possible role for
> buprenorphine in treating refractory depression. "
> Thanks again ANDREWB




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