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Re: reply to andrewb & Buprenorphine 4 depression

Posted by Diane on October 20, 1999, at 16:34:49

In reply to Re: Unconventional reaction to drugs.Opposite to norm, posted by andrewb on October 19, 1999, at 16:57:06

> You have an interesting story! Buprenorphine has been used to treat depression and is legally available without prescription from overseas.
> >

YOU wounldn't happen to have a particular vendor in mind would you?

I'd be VERY interested in that. Do you think
I was under the impression it was controlled same as Methadone.
but then I never even thought of overseas with regard to Buprenorphine. DAH!

Thanks I'm excited now.

Here's a what I believe they call an abstract. I found it here at:

" Opiates were used to treat major depression until the mid-1950s. The advent of opioids with
mixed agonist-antagonist or partial agonist activity, with reduced dependence and abuse
liabilities, has made possible the reevaluation of opioids for this indication. This is of potential
importance for the population of depressed patients who are unresponsive to or intolerant of
conventional antidepressant agents. Ten subjects with treatment-refractory, unipolar,
nonpsychotic, major depression were treated with the opioid partial agonist buprenorphine in an
open-label study. Three subjects were unable to tolerate more than two doses because of side
effects including malaise, nausea, and dysphoria. The remaining seven completed 4 to 6 weeks of
treatment and as a group showed clinically striking improvement in both subjective and objective
measures of depression. Much of this improvement was observed by the end of 1 week of
treatment and persisted throughout the trial. Four subjects achieved complete remission of
symptoms by the end of the trial (Hamilton Rating Scale for Depression scores < or = 6), two were
moderately improved, and one deteriorated. These findings suggest a possible role for
buprenorphine in treating refractory depression. "

Thanks again ANDREWB




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