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Re: serzone/nefazodone

Posted by Kaj on August 26, 1999, at 14:51:40

In reply to Re: serzone/nefazodone , posted by Cindy on August 23, 1999, at 20:23:07

Hi, I'm new to this board and have found the information quite helpful--thank you. I have some information that might also be useful to all of you...

My Dr. put me on an alternative dosage plan as researched by Markovitz in 1997. The study was designed to gauge what improvement this dosing plan had in patients with major depression...I don't see OCD or anxiety accounted for, nor drug interactions, but I only have one page of the study before me.

Basically, I take Serzone once a day, not twice, before bed, and up my dosage every four to six days (up to 600 mg.--I'm at 300 now.)

My hunch is that this cuts down a bit on the daytime drowsiness and fatigue. I've noticed that, if I take the drug at 11pm, I feel no side effects by 4pm the next day, which gives me some hours of "feeling normal". According to the research, this dosage plan also cuts the therapy time down by 2 months and achieves the same improvement.

I can't detect what effect the drug has had on my depression, but I can tell you the two-week vacation I'm on now has been excellent therapy. I highly recommend it.

A final note on Markovitz: I have searched the web for this research but can't find it online. My Dr. is on vacation (seems like they all go in August!) but if you'd be interested, e-mail me or post a note and I'll ask him.

Best to all--Kaj




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