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Re: reboxetine and...?

Posted by Adam on August 9, 1999, at 17:18:39

In reply to reboxetine and...?, posted by Elizabeth on August 8, 1999, at 21:44:33

I, of course, have no medical expertise to comment on the claims made by the authors of this paper, nor do I know much about
the quality of Italian research in psychopharmacology, but the abstract would suggest that not only is it safe to take reboxetine
and tranylcypromine (Parnate) at the same time, reboxetine may abrogate the cheese effect.

Again, I have no idea if one should take this notion seriously. From what I understand, though, part of the problem with tyramine
is that it is a norepinepherine mimetic, and binds to receptors on cells that are involved in regulation of blood pressure, sending
the wrong kinds of signals, somehow. I suppose that if there were something around that could boost the levels of NE, maybe there
would be enough around to out-compete tyramine binding. This is pure speculation on my part.

Couldn't hurt to run this by your doctors, though. I have heard that they are still trying to get reboxetine approved for marketing
in the USA, and that it could be available in less than a year.

Reboxetine prevents the tranylcypromine-induced
increase in tyramine levels in rat heart.
Dostert P, Castelli MG, Cicioni P, Strolin Benedetti M
Farmitalia Carlo Erba, Research and Development, Erbamont Group, Milan, Italy.
J Neural Transm Suppl 1994; 41:149-53


This study aimed to examine whether the increase in heart radioactivity levels after intravenous injection of
14C-tyramine to rats pretreated with the irreversible MAO inhibitor tranylcypromine could be antagonized by
reboxetine, a potent and selective noradrenaline uptake blocker. Reboxetine was found totally to abolish the effect
of tranylcypromine. Heart radioactivity levels after reboxetine and tranylcypromine were very similar to those found
when tyramine was injected after reboxetine only. These results suggest that reboxetine might be advantageously
combined with tranylcypromine, or any MAO inhibitor, in depressed patients unresponsive of either treatment given

> > Does anyone know if it's possible to comine these drugs? If there would be a reason to do so?
> Someone who lives in the UK or another country where reboxetine is used can probably answer this better than I can, but I think the answers are yes and yes.
> My question is, what about reboxetine and MAOIs? Have there been any interactions reported there? Is there any reason to think there would be?




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