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Re: Half-life of St. John's Wort?

Posted by JD on June 25, 1999, at 14:17:06

In reply to Re: Half-life of St. John's Wort?, posted by anita on June 23, 1999, at 22:28:47

I remember seeing an abstract on medline
(searchable via "PubMed" on the web) that discussed
the half-lives of the two major antidepressant
components of SJW, which I believe are hypericin
and pseudo-hypericin. Though they are of different
lengths, each is on the order of many days rather
than hours. My personal experience with SJW seems
to confirm this--it took a very long time, well
over a week, to feel like it was out of my system.
This is why I suggest that the best rule of thumb
might be to follow the washout guidelines for
starting an MAOI after Prozac treatment, as these
are necessarily pretty strict too.

> Thanks, JD. Can you give me a reference for this, i.e. how
> you found this out?
> anita




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