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Re: MAOIs, stimulants, and other things

Posted by JD on June 4, 1999, at 12:36:43

In reply to MAOIs, stimulants, and other things, posted by Elizabeth on June 4, 1999, at 11:49:27

Totally just kidding before--You do certainly know your stuff though!

Caffeine and nicotine apparently cause dopamine release through their antagonist actions at some other receptor (adenosine?). As for Parnate being "amphetamine-like", you're right, this one's been going on for a long time. For example, check out:

Is tranylcypromine really metabolized to amphetamine?
J Clin Psychiatry. 1992 Dec;53(12):450-1.

Current opinion, including a 1999 review of MAOI metabolism, seems to rule this out, but I guess this doesn't preclude Parnate from behaving "kind of like" amphetamine in some respects. (And it's certainly got an "upper-ish" reputation.) And yeah, as you note, selegiline definitely has an amphetamine metabolite. Perhaps this is one of the reasons I went for an unprecedented ten-mile run a few hours after trying a sensible eighth of a 5mg dose. (Can you say dopaminergic supersensitivity?) That one was a very short trial, even by my standards... Just another factor making me lean much more toward Nardil and/or Marplan if I ever try to join the MAOI big leagues. :-)


> > Ah, Elizabeth... Good to be reminded that there are people out there who know this stuff better than I do! ;-)
> Jeez, I didn't mean for it to come out like *that*! :-)

> >It's often said (and lately, I guess, often repeated by me) that Parnate is quite amphetamine-like in certain respects.
> What, like the molecule looks almost exactly like amphetamine? :-) Seriously, I heard that rumor too, that Parnate or one of its metabolites has amphetamine-like activity. Nobody's ever really put much effort into investigating it, although whenever they autopsy a Parnate OD, they always seem to look for amphetamines. (Oops, that was kind of morbid.)

> Now, *selegiline*, on the other hand, was jittery. Contrary to claims that have been made for it, I didn't find it as easy to tolerate as the other two MAOIs I've tried. (And it turns out that selegiline *does* have amphetamine metabolites - I even tested positive for them (how embarrassing).)




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