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sertraline, enzyme-inhibition, opioids...

Posted by paul on May 10, 1999, at 9:48:43

In reply to Re: Serzone and...- grapefruit/ anxiety/ + 2D6/3A4, posted by Mendel on May 8, 1999, at 1:20:17

This is tangentially related. As for enzyme inhibition, is sertraline the least inhibiting of the enzymes involved in the metabolism of oral opioids, i.e. codeine, hydrocodone?

I have noticed a somewhat diminished effect of hydrocodone while taking Zoloft, while a friend has noticed the same to a much greater extent with Paxil.

Are there any ways to "induce" these enzymes, or to prevent the inhibition of them while taking SSRIs?




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