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Re: buprenorphine experience

Posted by Elizabeth on April 5, 1999, at 23:04:57

In reply to Re: buprenorphine experience, posted by meleani on April 3, 1999, at 1:31:51

>It occurs to me to ask if
>you went with buprenorphine
>without considering a full
>antagonist like naltrexone
>first. If so, why? Great
>that the buprenex seems to
>be helping for you.

Buprenorphine acts primarily as an agonist at the doses used in depression. It's totally different from naltrexone or naloxone.

My understanding is that naltrexone is useful for certain impulsive behaviors (eating disorders, alcoholism and opiate-ism, self-injury) and for preventing ADs from losing effectiveness (or kick-staring them after they have pooped out), but is not much of an antidepressant by itself (and can even exacerbate some symptoms of depression). I did talk to my doctor and the consultant who originally suggested buprenorphine to me, and neither of them thought that ReVia was indicated in my case.




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