Psycho-Babble Medication | about biological treatments | Framed
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Re: Placebo effect in depression

Posted by alan on March 29, 1999, at 2:11:52

In reply to Re: Placebo effect in depression, posted by saintjames on March 25, 1999, at 16:50:56

> > I am doing research for a seminar involving the placebo effect
> > and the treatment of depression. Does anyone know of a well conducted
> > clinical trial comparing either:
> > placebo vs. patient interaction
> > placebo vs. active medication
> > or any combination of the sorts
> >
> James here.....
> In terms of placebo vs. active all AD's go through
> a clinical trial where this is used. Try going to the manufacture's site to find these studies.
> james

Recently, there wass a much publicized article in an e-journal. Donald Klein responded. I wish I could remember more, but I think I remember that it was a meta-analysis of many apparently well conducted studies (double blind etc); it concluded that ADs were not much better than placebo; most important--tho not brand new; same happened, at least with anti-psychotics, as I recall--subjects generally knew whether or not they were on the ADs or placebos from the side effects or lack thereof;
Moreover, if people keep trying one AD after another, they might either find something that works or simply remit and attribute it to the the meds they were on when they got better. I started tto glance at Klein's response where he complained about the tendency of e-journals to publish without adequate review. Ill look for it.




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