Psycho-Babble Medication | about biological treatments | Framed
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Re: your right, my screw-up

Posted by Jim on March 10, 1999, at 17:49:57

In reply to Re: positive amoxapine experience, posted by Elizabeth on March 9, 1999, at 23:27:07

Elizabeth wrote:
> Amoxapine isn't a dopamine *reuptake inhibitor*; it's a dopamine *antagonist*. That's what "blocks dopamine" means.
> MAOIs don't "block dopamine." They increase the amount of dopamine available by inhibiting its metabolism.
> I took amoxapine for 2 weeks or so, along with Parnate. It made me crave sugar to a point where I was really unfomfortable (must be what drug addicts feel like, I think), so I stopped. No other bad side effets, though, and no interaction with the Parnate.

Whoops, my slip... Not knowing amoxapine very well
I stupidly read "dopamine (i.e., receptor) blocking" as
"dopamine reuptake blocking," which as you note is
still not exactly the mechanism of MAO inhibition
(although functionally roughly similar).
Pretty dense of me especially given that a dopamine
reuptake blocker wouldn't be associated with
a risk of extrapyramidal side-effects! Thanks
for setting my lapse straight on this one.
Hope all continues to go well with Matt, too!
-- Jim




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