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Re: Atypical depression options

Posted by Jim on March 10, 1999, at 8:51:10

In reply to Re: Atypical depression options, posted by Elizabeth on March 9, 1999, at 23:43:09

Elizabeth wrote:

> Jim, you left out two salient features of atypical depression: chronic interpersonal sensitivity (not just while depressed, but as a trait throughout life), and feelings of extreme lethargy (especially feelings of "heaviness").

You're quite right, Elizabeth--though I suppose I was lumping the chronic sensitivity in as part of the general notion of "mood reactivity"... As I'm sure you know already, another frequently encountered term is "rejection sensitive", the flip-side of which is obviously feeling markedly better under positive conditions.

As for your naltrexone comments (which basically answer my question in the other thread about buprenorphine!), you're right that it's mostly been used adjunctively to jumpstart SSRIs or the like. I'm not convinced it causes dyphoria across the board however--several recent reports on alcoholism and various "impulse disorders" seem to suggest that it can help with depressive symptoms in certain patients even when used alone, but the jury's still out on this one.




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