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P450 drug interactions

Posted by Melanie on January 9, 1999, at 22:35:15

I recently attended a lecture on psychopharmacology
and learned that the SSRIs (with the exception of
the new one, Celexa) have a metabolite, cytochrome
P450 that causes Vicodin and Codeine to be less
effective when taken with the SSRIs (i.e. Paxil).
What can you tell me about this? I work as a Family
Nurse Practitioner in a chronic pain clinic where
a large majority of my patients are taking opiods as
well as anti-depressants.




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